Robert P. Millar

Professor, Mammal Research Institute, University of Pretoria, Pretoria, South Africa

Director, Centre for Neuroendocrinology, Institute for Cellular and Molecular Medicine, University of Pretoria, Pretoria, South Africa




Publications (2010-2015)

  1. Mayevu NM, Choe H, Abagyan R, Seong JY, Millar RP, Katz AA, Flanagan CA. (2015). Histidine 7.36 (305) in the conserved peptide receptor activation domain of the gonadotropin releasing hormone receptor couples peptide binding and receptor activation. Mol Cell Endocrinol . 402: 95-106.
  2. Moon MJ, Lee YN, Park S, Reyes-Alcaraz A, Hwang JI, Millar RP, Choe H, Seong JY. (2015). Ligand binding pocket formed by evolutionarily conserved residues in the glucagon-like   peptide-1 (GLP-1) receptor core domain. J Biol Chem. 290: 5696-5706.
  3. Karampelas T, Argyros O, Sayyad N, Spyridaki K, Pappas C, Morgan K, Kolios G, Millar RP, Liapakis G, Tzakos AG, Fokas D, Tamvakopoulos C. (2014). GnRH-Gemcitabine conjugates for the treatment of androgen-independent prostate cancer: pharmacokinetic enhancements combined with targeted drug delivery. Bioconjug Chem. 25(4):813-23
  4. Albers-Wolthers CH, De Gier J, Kooistra HS, Rutten VP, van Kooten PJ, de Graaf JJ, Leegwater PA, Millar RP, Okkens AC. (2014). Indentification of a novel kisspeptin with high gonadotropin stimulatory activity in the dog. Neuroendocrinol. 99(3-4):178-89
  5. Francis VA, Abera AB, Matjila M, Millar RP, Katz AA. (2014). Kisspeptin regulation of genes involved in cell invasion and angiogenesis in first trimester human trophoblast cells. Plos One. 9(6):e99680 doi:10.1371
  6. van Kesteren F, Piggott KJ, Bengui T, Kubri SB, Mastin A, Sillero-Zubiri C, Paris M, Millar RP, Macdonald DW, Shiferaw F, Craig PS. (2014). Helminth parasites in the endangered Ethiopian wolf, Canis Simensis. J Helminthol. 9:1-9
  7. Verma S, Kirigiti M, Millar RP, Grove KL, Smith SM. (2014). Endogenous kisspeptin tone is a critical excitatory component of spontaneous GnRH activity and the GnRH response to NPY and CART. Neuroendocrinol. 99:190-203
  8. Anderson RC, Newton CL, Millar RP, Katz AA. (2014). The Brugia malayi neuropeptide receptor -4 is activated by FMR Famide-like peptides and signals via Gai. Mol Biochem Parasitol. 195(1):54-58
  9. Popovics P, Lu J, Nadia Kamil L, Morgan K, Millar RP, Schmid R, Blindauer CA, Stewart AJ. (2014). A canonical EF-loop directs Ca(2+) – sensitivity in phosphokipase C-ή2. J Cell Biochem. 115(3):557-65
  10. Knoll JG, Clay CM, Bouma GJ, Henion TR, Schwarting GA, Millar RP, Tobet SA. (2013). Developmental profile and sexually dimorphic expression of kiss1 and kiss1r in the fetal mouse brain. Front Endocrinol. (Lausanne) 4:140
  11. Munro KI, Thrippleton MJ, Williams AR, McKillop G, Walker J, Horne AW, Newby DE, Anderson RA, Semple SI, Marshall I, Lewis SC, Millar RP, Bastin ME, Critchley HO. (2014). Quantitive Serial MRI of the Treated Fibroid Uterus. PLoS One, 9(3): 89809
  12. Goodman RL, Hileman SM, Nestor CC, Porter KL, Connors JM, Hardy SL, Millar RP, Cernea M, Coolen LM, Lehman MN (2013). Kisspeptin, neurokinin B and dynorphin act in the arcuate nucleus to control activity of the GnRH pulse generator in ewes. Endocrinol. 154(11):4259-69.
  13. van Kesteren FF, Paris M, Macdonald DW, Millar R, Argaw K, Johnson PJ, Farstad W, Sillero-Zubiri C (2013). The physiology of cooperative breeding in a rare social canid: sex, suppression and pseudopregnancy in female Ethiopian wolves. Physil Behav, 122C:39-45.
  14. Van Der Goot AC, Dalerum F, Ganswindt A, Martin GB, Millar RP, Paris MCJ (2013). Faecal progestagen profiles in wild southern white rhinoceros (Ceratotherium simum simum). African Zoology. 48:143-151.
  15. Maione L, Albarel F, Bouchard P, Gallant M, Flanagan CA, Bobe R, Cohen-Tannoudji J, Pivonello R, Colao A, Brue T, Millar RP, Lombes M, Young J, Guiochon-Mantel A, Bouligand J (2013). R31C GnRH1 Mutation and Congenital Hypogonadotropic Hypogonadism. Plos ONE. 8(7):69616.
  16. Tello JA, Kohout T, Pineda R, Maki RA, Struthers RS, Millar RP (2013). Reproductive physiology of a humanized GnRH receptor mouse model: application in evaluation of human-specific analogs. American Journal of Physiology-Endocrinology and Metabolism. 305:67-77.
  17. George JT, Veldhuis JD, Tena-Sempere M, Millar RP, Anderson RA. (2013). Exploring the Pathophysiology of hyopgonadism in men with type 2 diabetes: Kisspeptin-10 stimulates serum testosterone and LH secretion in men with type 2 diabetes and mild biochemical hypogonadism. Clinical Endocrinol. 79:100-104.
  18. Park CR, Moon MJ, Park S, Kim DK, Cho EB, Millar RP, Hwang JI, Seong JY. (2013). A Novel Glucagon-Related Peptide (GCRP) and its Receptor GCRPR account for Coevolution of their family members in vertebrates. Plos ONE, 8(6):65420.
  19. Lashkari HP, Nash R, Albanese AA, Okoye B, Millar RP, Pritchard-Jones K. (2013).       Treatment of high risk Sertoli-Leydig cell tumors of the ovary using a gonadotropin releasing hormone (GnRH) analog. Pediatric Blood & Cancer, 60:16-18.
  20. Meyer C, Sims AH, Morgan K, Harrison B, Muir MM, Bai JN, Faratian D, Millar RP, Langdon SP, Simon P (2013). Transcript and protein identifies signalling, growth arrest, apoptosis, and NF-kappa B survival signatures following GnRH receptor activation. Endocrine-related cancer. 20:123-136.
  21. De Bond JAP, Li Q, Millar RP, Clarke IJ, Smith JT (2013). Kisspeptin signaling is required for the luteinizing hormone response in anestrous ewes following the introduction of Males. Plos ONE. 8(2): 57972.
  22. Young J, George JT, Tello JA, Francou B, Bouligand J, Guiochon-Mantel A, Brailly-               Tabard S, Anderson RA, Millar RP. (2013). Kisspeptin restores pulsatile LH secretion in         patients with Neurokinin B signaling deficiencies: Physiological, Pathophysiological and Therapeutic Implications. Neuroendocrinol. 97(2):193-
  23. Ermakov A, Pells S, Freile P, Ganeva VV, Wildenhain J, Bradley M, Pawson A, Millar R, De Sousa PA. (2012). A role for intracellular calcium downstream of G-protein signaling in undifferentiated human embryonic stem cell culture. Stem Cell Res, 9(3):171-84
  24. Hasting JM, Morris KD, Allan D, Wilson H, Millar RP, Fraser HM, Moran CM. (2012). Contrast imaging ultrasound detects abnormalities in the marmoset ovary. Am J Primatol, 74(12): 1088-96.
  25. Van Kesteren F, Sillero-Zubiri C, Millar R, Argaw K, Macdonald D.W, Paris M (2012). Sex, stress and social status: Patterns in fecal testosterone and glucocorticoid metabolites in male Ethiopian wolves. General and Comparative Endocrinol. 179(1):30-37.
  26. Sonigo C, Bouilly J, Carré N, Tolle V, Caraty A, Tello J, Simony-Conesa FJ, Millar R, Young J, Binart N. (2012). Hyperprolactinemia-induced ovarian acyclicity is reversed by kisspeptin administration . Journal of Clinical Investigation, 122(10): 3791-3795.
  27. Grachev P, Li XF, Kinsey-Jones JS, Di Domenico AL, Millar RP, Lightman SL, O’Byrne, K. (2012). Suppression of the GnRH pulse generator by neurokinin B involves a κ- opioid       receptor-dependent mechanism. Endocrinol. 153(10): 4894-4904.
  28. George JT, Anderson RA, Millar RP. (2012). Kisspeptin-10 stimulation of gonadotrophin secretion in women is modulated by sex steroid feedback. Human Reproduction, 27(12): 3552-3559.
  29. Goodman RL, Maltby MJ, Millar RP, Hileman, SM, Nestor CC, Whited B, Tseng AS, Coolen LM, Lehman MN (2012). Evidence that dopamine acts via kisspeptin to hold GnRH pulse frequency in check in anestrous ewes. Endocrinol. 153(12): 5918-5927.
  30. Grachev P, Li XF, Lin YS, Hu MH, Elsamani L, Paterson SJ, Millar RP, Lightman SL, O’Byrne KT. (2012). GPR54-Dependent stimulation of luteinizing hormone secretion by Neurokinin B in prepubertal rats. PLoS ONE. 7(9):44344.
  31. Tello JA, Newton CL, Bouligand J, Guiochon-Mantel A, Millar RP, Young J. (2012). Congenital hypogonadotropic hypogonadism due to GNRH receptor mutations in three brothers reveal sites affecting conformation and coupling. PLoS ONE. 7(6):38456.
  32. Topaloglu AK, Tello JA, Kotan LD, Ozbek M MN, Yilmaz MB, Erdogan S, Gurbuz F,           Temiz F, Millar RP, Yuksel B. (2012). Inactivating KISS1 mutation and hypogonadotropic hypogonadism. New England Journal of Medicine, 16;366(7):629-35
  33. Matjila M, Millar R, Katz A. et al. (2012). The differential expression of Kiss 1,  MMP9 and angiogenic regulators in different feto-maternal compartments of healthy pregnancies: implications for trophoblast invation and vessel development. Placenta. Vol: 33(9):46.
  34. Son YL, Ubuka T, Millar RP, Kanasaki H, Tsutsui K. (2012). Gonadotropin-Inhibitory hormone inhibits GnRH Induced gonadotropin subunit gene transcriptions by inhibiting AC/cAMP/PKA-Dependent ERK pathway in LβT2 Cells. Endocrinol. 153(5): 2332-43.
  35. Roseweir AK, Katz AA, Millar RP. (2012). Kisspeptin-10 inhibits cell migration in vitro via a receptor-GSK3 beta-FAK feedback loop in HTR8SV neo cells. Placenta. 33(5):408-15.
  36. Clarke IJ, Smith JT, Henry BA, Oldfield BJ, Stefanidis A, Millar RP, Sari IP, Chng K, Fabre-Nys C, Caraty A, Ang BT, Chan L, Fraley GS (2012). Gonadotropin-Inhibitory Hormone Is a Hypothalamic Peptide That Provides a Molecular Switch between Reproduction and Feeding.Neuroendocrinol. 95(4): 305-316.
  37. Guerriero KA, Keen KL, Millar RP, Terasawa E. (2012). Developmental changes in GnRH release in response to kisspeptin agonist and antagonist in female rhesus monkeys (Macaca mulatta): implication for the mechanism of puberty. Endocrinol. 153(2): 825-36.
  38. Morgan K, Meyer C, Miller N, Sims AH, Cagnan I, Faratian D, Harrison DJ, Millar RP, Langdon SP. (2011). GnRH receptor activation competes at a low level with growth signaling in stably transfected human breast cell lines. BMC Cancer. 11:476.
  39. George JT, Veldhuis JD, Roseweir AK, Newton CL, Faccenda E, Millar RP, Anderson RA. (2011). Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men Journal of Clinical Endocrinol and Metabolism. 96(8):1228-1236.
  40. Newton CL, Whay AM, McArdle CA, Zhang M, Van Koppen CJ, Van De Lagemaat R, Segaloff DL, Millar RP. (2011). Rescue of expression and signaling of human luteinizing hormone G protein-coupled receptor mutants with an allosterically binding small-molecule agonist Proceedings of the National Academy of Sciences of the United States of America. 108(17)7172-7176.
  41. Popovics P, Beswick W, Guild SB, Cramb G, Morgan K, Millar RP, Stewart AJ. (2011). Phospholipase C-η2 is activated by elevated intracellular Ca(2+) levels. Cell Signal. (11):1777-84.
  42. Smith JT, Qun L, Yap KS, Shahab M, Roseweir AK, Millar RP, Clarke IJ (2010). Kisspeptin is essential for the full ovine preovulatory LH surge and stimulates GnRH release from the isolated median eminence. Endocrinology, 152(3): 1001-1012.
  43. Liu X, Porteous R, d’Anglemont de Tassingy X, Colledge W, Millar R, Petersen S, Herbison A (2011). Frequency-dependent recruitment of fast and slow neurotransmitter release controls gonadotropin-releasing hormone neuron excitability. The Journal of Neuroscience, 31(7): 2421-30.
  44. Morgan K, Stavrou E, Leighton SP, Miller N, Sellar R, Millar R (2010). Elevated GnRH receptor expression plus GnRH agonist treatment inhibits the growth of a subset of papillomavirus 18-immortalized human prostate cells. Prostate, 71(9): 915-928.
  45. Ramaesh T, Logie JJ, Millar RP, Walker BR, Hadoke PWF, Roseweir A, Reynolds RM (2010). Kisspeptin-10 inhibits angiogenesis in human placental vessels ex vivo and endothelial cells in vitro. Endocrinology, 151, 5927-5934.
  46. Teixeira L, Guimiot F, Dode C, Fallet-Bianco C, Millar RP, Delezoide A-L, Hardelin J-P (2010). Defective migration of neuroendocrine GnRH-cells in various human arrhinencephalic conditions. Journal of Clinical Investigation, 120, 3668-3672.
  47. Re M, Pampillo M, Savard M, Dubuc C, McArdle CA, Millar RP, Conn PM, Gobeil F Jr, Bhattacharya M, Babwah AV (2010). The human gonadotropin releasing hormone type I receptor is a functional intracellular GPCR expressed on the nuclear membrane. PLoS One, 5(7):11489.
  48. McEwan IJ, McGuiness D, Hay CW, Millar RP, Saunders PTK, Fraser HM (2010). Identification of androgen receptor phosphorylation in the primate ovary in vivo. Reproduction, 140, 93-104.
  49. Naidich M, Shterntal B, Furman R, Pawson AJ, Jabbour HN, Morgan K, Millar RP, Jia J, Tomic M, Stojilkovic S, Stern N, Naor Z (2010). Elucidation of Mechanisms of the Reciprocal Cross-talk between Gonadotropin-releasing Hormone (GnRH) and Prostaglandin Receptors. Endocrinology, 151, 2700-2712.

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